Anti-Phospho-SHC3-Tyr424 antibody (STJA0009985)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Shc3 (Phospho-Tyr424)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-SHC-transforming protein 3-Tyr424 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SHC3 |
| Gene ID | 53358 |
| Uniprot ID | SHC3_HUMAN |
| Immunogen | Synthesized peptide derived from human Shc3 (Phospho-Tyr424) |
| Specificity | This antibody detects endogenous levels of Shc3 (Phospho-Tyr424) at Human, Mouse, Rat |
Additional Info
| Tissue Specificity | Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. |
| Protein Name | Shc-Transforming Protein 3Neuronal ShcN-ShcProtein RaiShc-Transforming Protein CSrc Homology 2 Domain-Containing-Transforming Protein C3Sh2 Domain Protein C3 |
| Database Links | Reactome: R-HSA-167044Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Shc-Transforming Protein 3 antibodyAnti-Neuronal Shc antibodyAnti-N-Shc antibodyAnti-Protein Rai antibodyAnti-Shc-Transforming Protein C antibodyAnti-Src Homology 2 Domain-Containing-Transforming Protein C3 antibodyAnti-Sh2 Domain Protein C3 antibodyAnti-SHC3 antibodyAnti-NSHC antibodyAnti-SHCC antibody |
Information sourced from Uniprot.org