| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-SHC-transforming protein 3-Tyr424 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SHC3 |
| Gene ID: |
53358 |
| Uniprot ID: |
SHC3_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Shc3 (Phospho-Tyr424) at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human Shc3 (Phospho-Tyr424) |
| Tissue Specificity | Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. |
| Protein Name | Shc-Transforming Protein 3Neuronal ShcN-ShcProtein RaiShc-Transforming Protein CSrc Homology 2 Domain-Containing-Transforming Protein C3Sh2 Domain Protein C3 |
| Database Links | Reactome: R-HSA-167044Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Alternative Antibody Names | Anti-Shc-Transforming Protein 3 antibodyAnti-Neuronal Shc antibodyAnti-N-Shc antibodyAnti-Protein Rai antibodyAnti-Shc-Transforming Protein C antibodyAnti-Src Homology 2 Domain-Containing-Transforming Protein C3 antibodyAnti-Sh2 Domain Protein C3 antibodyAnti-SHC3 antibodyAnti-NSHC antibodyAnti-SHCC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
