| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-cGMP-dependent protein kinase 2-Ser126 (92-141 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRKG2 |
| Gene ID: | 5593 |
| Uniprot ID: | KGP2_HUMAN |
| Immunogen Region: | 92-141 aa |
| Specificity: | Phospho-cGKII (S126) Polyclonal Antibody detects endogenous levels of cGKII protein only when phosphorylated at S126. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PKG2 around the phosphorylation site of Ser126 at the amino acid range 92-141 |
| Post Translational Modifications | Myristoylation mediates membrane localization. |
| Function | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. |
| Protein Name | Cgmp-Dependent Protein Kinase 2 Cgk 2 Cgk2 Cgmp-Dependent Protein Kinase Ii Cgkii |
| Database Links | Reactome: R-HSA-1474151 Reactome: R-HSA-4086398 Reactome: R-HSA-418457 Reactome: R-HSA-9648002 |
| Cellular Localisation | Apical Cell Membrane Lipid-Anchor |
| Alternative Antibody Names | Anti-Cgmp-Dependent Protein Kinase 2 antibody Anti-Cgk 2 antibody Anti-Cgk2 antibody Anti-Cgmp-Dependent Protein Kinase Ii antibody Anti-Cgkii antibody Anti-PRKG2 antibody Anti-PRKGR2 antibody |
Information sourced from Uniprot.org