Anti-Phospho-PRKG2-Ser126 antibody (92-141 aa) (STJ91216)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PKG2 around the phosphorylation site of Ser126 at the amino acid range 92-141
General Information
| Short Description | Rabbit polyclonal anti-Phospho-cGMP-dependent protein kinase 2-Ser126 (92-141 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRKG2 |
| Gene ID | 5593 |
| Uniprot ID | KGP2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PKG2 around the phosphorylation site of Ser126 at the amino acid range 92-141 |
| Immunogen Region | 92-141 aa |
| Specificity | Phospho-cGKII (S126) Polyclonal Antibody detects endogenous levels of cGKII protein only when phosphorylated at S126. |
Additional Info
| Post Translational Modifications | Myristoylation mediates membrane localization. |
| Function | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. |
| Protein Name | Cgmp-Dependent Protein Kinase 2Cgk 2Cgk2Cgmp-Dependent Protein Kinase IiCgkii |
| Database Links | Reactome: R-HSA-1474151Reactome: R-HSA-4086398Reactome: R-HSA-418457Reactome: R-HSA-9648002 |
| Cellular Localisation | Apical Cell MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-Cgmp-Dependent Protein Kinase 2 antibodyAnti-Cgk 2 antibodyAnti-Cgk2 antibodyAnti-Cgmp-Dependent Protein Kinase Ii antibodyAnti-Cgkii antibodyAnti-PRKG2 antibodyAnti-PRKGR2 antibody |
Information sourced from Uniprot.org