• Western blot analysis of lysates from HeLa cells treated with TNF-alpha 20ng/ml 5', using ICAM-1 (Phospho-Tyr512) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of various cells using Phospho-ICAM-1 (Y512) Polyclonal Antibody diluted at 1：500

Anti-Phospho-ICAM1-Tyr512 antibody (479-528 aa) (STJ90297)

SKU:
STJ90297

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Intercellular adhesion molecule 1-Tyr512 (479-528 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ICAM1
Gene ID: 3383
Uniprot ID: ICAM1_HUMAN
Immunogen Region: 479-528 aa
Specificity: Phospho-ICAM-1 (Y512) Polyclonal Antibody detects endogenous levels of ICAM-1 protein only when phosphorylated at Y512.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ICAM-1 around the phosphorylation site of Tyr512 at the amino acid range 479-528
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Protein Name Intercellular Adhesion Molecule 1
Icam-1
Major Group Rhinovirus Receptor
Cd Antigen Cd54
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-216083
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Intercellular Adhesion Molecule 1 antibody
Anti-Icam-1 antibody
Anti-Major Group Rhinovirus Receptor antibody
Anti-Cd Antigen Cd54 antibody
Anti-ICAM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance