Anti-Phospho-Histone H2A-Thr121 antibody (81-130 aa) (STJ91231)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Histone H2A around the phosphorylation site of Thr121 at the amino acid range 81-130
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Histone H2A type 1 and Histone H2A type 1-B/E and Histone H2A type 1-D and Histone H2A type 1-H and Histone H2A type 2-A and Histone H2A type 3-Thr121 (81-130 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | H2AC4.H2AC8H2AC73012/83353013 |
| Uniprot ID | H2A1B_HUMANH2A1D_HUMANH2A1_HUMAN< |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Histone H2A around the phosphorylation site of Thr121 at the amino acid range 81-130 |
| Immunogen Region | 81-130 aa |
| Specificity | Phospho-Histone H2A (T121) Polyclonal Antibody detects endogenous levels of Histone H2A protein only when phosphorylated at T121. |
Additional Info
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Protein Name | Histone H2a Type 1H2a.1Histone H2a/Ptl |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-5689603Reactome: R-HSA-5689880Reactome: R-HSA-5689901Reactome: R-HSA-9609690Reactome: R-HSA-9610379 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone H2a Type 1 antibodyAnti-H2a.1 antibodyAnti-Histone H2a/Ptl antibodyAnti-H2AC11 antibodyAnti-H2AFP antibodyAnti-HIST1H2AG.H2AC13 antibodyAnti-H2AFC antibodyAnti-HIST1H2AI.H2AC15 antibodyAnti-H2AFD antibodyAnti-HIST1H2AK.H2AC16 antibodyAnti-H2AFI antibodyAnti-HIST1H2AL.H2AC17 antibodyAnti-H2AFN antibodyAnti-HIST1H2AM antibody |
Information sourced from Uniprot.org