Anti-Phospho-HCLS1-Tyr397 antibody (366-415 aa) (STJ90644)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human HS1 around the phosphorylation site of Tyr397 at the amino acid range 366-415
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Hematopoietic lineage cell-specific protein-Tyr397 (366-415 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HCLS1 |
| Gene ID | 3059 |
| Uniprot ID | HCLS1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human HS1 around the phosphorylation site of Tyr397 at the amino acid range 366-415 |
| Immunogen Region | 366-415 aa |
| Specificity | Phospho-Lck BP-1 (Y397) Polyclonal Antibody detects endogenous levels of Lck BP-1 protein only when phosphorylated at Y397. |
Additional Info
| Post Translational Modifications | Phosphorylated by FES. Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. |
| Function | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| Protein Name | Hematopoietic Lineage Cell-Specific ProteinHematopoietic Cell-Specific Lyn Substrate 1Lckbp1P75 |
| Database Links | |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Hematopoietic Lineage Cell-Specific Protein antibodyAnti-Hematopoietic Cell-Specific Lyn Substrate 1 antibodyAnti-Lckbp1 antibodyAnti-P75 antibodyAnti-HCLS1 antibodyAnti-HS1 antibody |
Information sourced from Uniprot.org