| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-Fibroblast growth factor receptor substrate 2-Tyr436 (402-451 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FRS2 |
| Gene ID: | 10818 |
| Uniprot ID: | FRS2_HUMAN |
| Immunogen Region: | 402-451 aa |
| Specificity: | Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human FRS2 around the phosphorylation site of Tyr436 at the amino acid range 402-451 |
| Post Translational Modifications | Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases.this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. |
| Function | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. |
| Protein Name | Fibroblast Growth Factor Receptor Substrate 2Fgfr Substrate 2Fgfr-Signaling Adaptor SntSuc1-Associated Neurotrophic Factor Target 1Snt-1 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-170968Reactome: R-HSA-201556Reactome: R-HSA-2219530Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654700Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-9028731Reactome: R-HSA-9696270Reactome: R-HSA-9696273Reactome: R-HSA-9725370 |
| Cellular Localisation | Endomembrane SystemCytoplasmicMembrane-Bound |
| Alternative Antibody Names | Anti-Fibroblast Growth Factor Receptor Substrate 2 antibodyAnti-Fgfr Substrate 2 antibodyAnti-Fgfr-Signaling Adaptor Snt antibodyAnti-Suc1-Associated Neurotrophic Factor Target 1 antibodyAnti-Snt-1 antibodyAnti-FRS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
