• Western blot analysis of lysates from COS7 cells, using FRS2 (Phospho-Tyr436) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of COS cells using Phospho-FRS2 (Y436) Polyclonal Antibody
  • Immunohistochemistry analysis of paraffin-embedded human brain, using FRS2 (Phospho-Tyr436) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of various cells using Phospho-FRS2 (Y436) Polyclonal Antibody

Anti-Phospho-FRS2-Tyr436 antibody (402-451 aa) (STJ90965)

SKU:
STJ90965

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Fibroblast growth factor receptor substrate 2-Tyr436 (402-451 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FRS2
Gene ID: 10818
Uniprot ID: FRS2_HUMAN
Immunogen Region: 402-451 aa
Specificity: Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436.
Immunogen: The antiserum was produced against synthesized peptide derived from the human FRS2 around the phosphorylation site of Tyr436 at the amino acid range 402-451
Post Translational Modifications Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases.this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.
Function Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Protein Name Fibroblast Growth Factor Receptor Substrate 2
Fgfr Substrate 2
Fgfr-Signaling Adaptor Snt
Suc1-Associated Neurotrophic Factor Target 1
Snt-1
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-170968
Reactome: R-HSA-201556
Reactome: R-HSA-2219530
Reactome: R-HSA-5654689
Reactome: R-HSA-5654693
Reactome: R-HSA-5654695
Reactome: R-HSA-5654700
Reactome: R-HSA-5654706
Reactome: R-HSA-5654710
Reactome: R-HSA-5654712
Reactome: R-HSA-5654720
Reactome: R-HSA-5654726
Reactome: R-HSA-5654727
Reactome: R-HSA-5654732
Reactome: R-HSA-5654733
Reactome: R-HSA-5655253
Reactome: R-HSA-5655291
Reactome: R-HSA-5655302
Reactome: R-HSA-5655332
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-8853659
Reactome: R-HSA-9028731
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Reactome: R-HSA-9725370
Cellular Localisation Endomembrane System
Cytoplasmic
Membrane-Bound
Alternative Antibody Names Anti-Fibroblast Growth Factor Receptor Substrate 2 antibody
Anti-Fgfr Substrate 2 antibody
Anti-Fgfr-Signaling Adaptor Snt antibody
Anti-Suc1-Associated Neurotrophic Factor Target 1 antibody
Anti-Snt-1 antibody
Anti-FRS2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance