| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Dual specificity protein phosphatase 16-Ser446 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DUSP16 |
| Gene ID: |
80824 |
| Uniprot ID: |
DUS16_HUMAN |
| Specificity: |
This antibody detects endogenous levels of MKP-7 (Phospho-Ser446) at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human MKP-7 (Phospho-Ser446) |
| Post Translational Modifications | Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity. (Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein.this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis. |
| Function | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. |
| Protein Name | Dual Specificity Protein Phosphatase 16Mitogen-Activated Protein Kinase Phosphatase 7Map Kinase Phosphatase 7Mkp-7 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5675221Reactome: R-HSA-9636569Reactome: R-HSA-9652817 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic VesicleAfter Dissociation Upon Agtr StimulationRe-Associates With Arrb2 On Endocytic Vesicles |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 16 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 7 antibodyAnti-Map Kinase Phosphatase 7 antibodyAnti-Mkp-7 antibodyAnti-DUSP16 antibodyAnti-KIAA1700 antibodyAnti-MKP7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
