Anti-Phospho-DUSP16-Ser446 antibody (STJA0009999)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MKP-7 (Phospho-Ser446)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Dual specificity protein phosphatase 16-Ser446 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DUSP16 |
| Gene ID | 80824 |
| Uniprot ID | DUS16_HUMAN |
| Immunogen | Synthesized peptide derived from human MKP-7 (Phospho-Ser446) |
| Specificity | This antibody detects endogenous levels of MKP-7 (Phospho-Ser446) at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity. (Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein.this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis. |
| Function | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. |
| Protein Name | Dual Specificity Protein Phosphatase 16Mitogen-Activated Protein Kinase Phosphatase 7Map Kinase Phosphatase 7Mkp-7 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5675221Reactome: R-HSA-9636569Reactome: R-HSA-9652817 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic VesicleAfter Dissociation Upon Agtr StimulationRe-Associates With Arrb2 On Endocytic Vesicles |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 16 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 7 antibodyAnti-Map Kinase Phosphatase 7 antibodyAnti-Mkp-7 antibodyAnti-DUSP16 antibodyAnti-KIAA1700 antibodyAnti-MKP7 antibody |
Information sourced from Uniprot.org