Anti-Phospho-DLG2-Y340 antibody (STJ11101118)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Phospho-DLG2-Y340 antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DLG2 |
| Gene ID | 1740 |
| Uniprot ID | DLG2_HUMAN |
| Immunogen Sequence | DDYTR |
| Specificity | A synthetic phosphorylated peptide around Y340 of human PSD93/chapsyn-110/DLG2 (NP_001355.2). |
Additional Info
| Post Translational Modifications | Palmitoylation of isoform 1 is not required for targeting to postsynaptic density. |
| Function | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. |
| Protein Name | Disks Large Homolog 2Channel-Associated Protein Of Synapse-110Chapsyn-110Postsynaptic Density Protein Psd-93 |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneLipid-AnchorPostsynaptic DensitySynapseMembraneCell ProjectionAxonPerikaryonConcentrated In Soma And Postsynaptic Density Of A Subset Of Neurons |
| Alternative Antibody Names | Anti-Disks Large Homolog 2 antibodyAnti-Channel-Associated Protein Of Synapse-110 antibodyAnti-Chapsyn-110 antibodyAnti-Postsynaptic Density Protein Psd-93 antibodyAnti-DLG2 antibody |
Information sourced from Uniprot.org