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Anti-Phospho-CCNE1-Ser399 antibody (STJA0010041)

Anti-Phospho-CCNE1-Ser399 antibody (STJA0010041)

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STJA0010041

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	IHC/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phospho-G1/S-specific cyclin-E1-Ser399 is suitable for use in Immunohistochemistry and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 IHC 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCNE1
Gene ID:	898
Uniprot ID:	CCNE1_HUMAN
Specificity:	This antibody detects endogenous levels of Cyclin E1 (Phospho Ser399) Rabbit pAb at Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human Cyclin E1 (Phospho Ser399)

Tissue Specificity	Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Post Translational Modifications	Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation.
Function	Essential for the control of the cell cycle at the G1/S (start) transition.
Protein Name	G1/S-Specific Cyclin-E1
Database Links	Reactome: R-HSA-1538133 Reactome: R-HSA-187577 Reactome: R-HSA-2559586 Reactome: R-HSA-390471 Reactome: R-HSA-6804116 Reactome: R-HSA-69017 Reactome: R-HSA-69200 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69563 Reactome: R-HSA-8849470 Reactome: R-HSA-9661069 Reactome: R-HSA-9706019
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-G1/S-Specific Cyclin-E1 antibody Anti-CCNE1 antibody Anti-CCNE antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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