Anti-Phospho-CAPN2-Ser50 antibody (STJA0009846)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Calpain 2 (Phospho Ser50)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Calpain-2 catalytic subunit-Ser50 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAPN2 |
| Gene ID | 824 |
| Uniprot ID | CAN2_HUMAN |
| Immunogen | Synthesized peptide derived from human Calpain 2 (Phospho Ser50) |
| Specificity | This antibody detects endogenous levels of Human, Mouse, Rat Calpain 2 (Phospho Ser50) |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| Protein Name | Calpain-2 Catalytic SubunitCalcium-Activated Neutral Proteinase 2Canp 2Calpain M-TypeCalpain Large Polypeptide L2Calpain-2 Large SubunitMillimolar-CalpainM-Calpain |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-8862803Reactome: R-HSA-9856530Reactome: R-HSA-9860927 |
| Cellular Localisation | CytoplasmCell MembraneTranslocates To The Plasma Membrane Upon Ca(2+) Binding |
| Alternative Antibody Names | Anti-Calpain-2 Catalytic Subunit antibodyAnti-Calcium-Activated Neutral Proteinase 2 antibodyAnti-Canp 2 antibodyAnti-Calpain M-Type antibodyAnti-Calpain Large Polypeptide L2 antibodyAnti-Calpain-2 Large Subunit antibodyAnti-Millimolar-Calpain antibodyAnti-M-Calpain antibodyAnti-CAPN2 antibodyAnti-CANPL2 antibody |
Information sourced from Uniprot.org