| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Calpain-2 catalytic subunit-Ser50 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAPN2 |
| Gene ID: | 824 |
| Uniprot ID: | CAN2_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human, Mouse, Rat Calpain 2 (Phospho Ser50) |
| Immunogen: | Synthesized peptide derived from human Calpain 2 (Phospho Ser50) |
| Tissue Specificity | Ubiquitous. |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| Protein Name | Calpain-2 Catalytic Subunit Calcium-Activated Neutral Proteinase 2 Canp 2 Calpain M-Type Calpain Large Polypeptide L2 Calpain-2 Large Subunit Millimolar-Calpain M-Calpain |
| Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-8862803 |
| Cellular Localisation | Cytoplasm Cell Membrane Translocates To The Plasma Membrane Upon Ca(2+) Binding |
| Alternative Antibody Names | Anti-Calpain-2 Catalytic Subunit antibody Anti-Calcium-Activated Neutral Proteinase 2 antibody Anti-Canp 2 antibody Anti-Calpain M-Type antibody Anti-Calpain Large Polypeptide L2 antibody Anti-Calpain-2 Large Subunit antibody Anti-Millimolar-Calpain antibody Anti-M-Calpain antibody Anti-CAPN2 antibody Anti-CANPL2 antibody |
Information sourced from Uniprot.org