Anti-Phospho-ATP1A1-Ser16 antibody (5-54 aa) (STJ90804)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ATPase around the phosphorylation site of Ser16 at the amino acid range 5-54
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Sodium/potassium-transporting ATPase subunit alpha-1/K+ ATPase alpha-1 subunit-Ser16 (5-54 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and rela |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATP1A1 |
| Gene ID | 476 |
| Uniprot ID | AT1A1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ATPase around the phosphorylation site of Ser16 at the amino acid range 5-54 |
| Immunogen Region | 5-54 aa |
| Specificity | Phospho-Na+/K+-ATPase Alpha 1 (S16) Polyclonal Antibody detects endogenous levels of Na+/K+-ATPase Alpha 1 protein only when phosphorylated at S16. |
Additional Info
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis. |
| Protein Name | Sodium/Potassium-Transporting Atpase Subunit Alpha-1Na(+/K(+ Atpase Alpha-1 SubunitSodium Pump Subunit Alpha-1 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneSarcolemmaCell ProjectionAxonMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Sodium/Potassium-Transporting Atpase Subunit Alpha-1 antibodyAnti-Na(+/K(+ Atpase Alpha-1 Subunit antibodyAnti-Sodium Pump Subunit Alpha-1 antibodyAnti-ATP1A1 antibody |
Information sourced from Uniprot.org