Anti-Phospho-14-3-3-Ser58 antibody (STJA0003567)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser58 conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Phospho-14-3-3-Ser58 for use in WB and IHC in Human, Mouse, Rat, Bovine, Canine, Chicken, Non-Human Primates, Sheep, Xenopus and Zebrafish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Bovine/Canine/Chicken/Non-Human Primates/Sheep/Xenopus/Zebrafish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000IHC 1:100-1:500 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Ywhab |
| Gene ID | 56011 |
| Uniprot ID | 1433B_RAT |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser58 conjugated to KLH. |
Additional Info
| Post Translational Modifications | The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Isoform Short contains a N-acetylmethionine at position 1. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
| Protein Name | 14-3-3 Protein Beta/AlphaPrepronerve Growth Factor Rnh-1Protein Kinase C Inhibitor Protein 1Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed |
| Database Links | Reactome: R-RNO-111447Reactome: -RNO-165159Reactome: -RNO-166208Reactome: -RNO-170968Reactome: -RNO-2028269Reactome: -RNO-392517Reactome: -RNO-450385Reactome: -RNO-450513Reactome: -RNO-5625740Reactome: -RNO-5628897Reactome: -RNO-5673000Reactome: -RNO-5674135Reactome: -RNO-5675221Reactome: -RNO-75035Reactome: -RNO-9614399 |
| Cellular Localisation | CytoplasmMelanosome |
| Alternative Antibody Names | Anti-14-3-3 Protein Beta/Alpha antibodyAnti-Prepronerve Growth Factor Rnh-1 antibodyAnti-Protein Kinase C Inhibitor Protein 1 antibodyAnti-Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed antibodyAnti-Ywhab antibody |
Information sourced from Uniprot.org