| Short Description : | Rabbit polyclonal PEX19 (1-299) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PEX19 |
| Gene ID: | 5824 |
| Uniprot ID: | PEX19_HUMAN |
| Immunogen Region: | 1-299 |
| Immunogen Sequence: | MAAAEEGCSVGAEADRELEE LLESALDDFDKAKPSPAPPS TTTAPDASGPQKRSPGDTAK DALFASQEKFFQELFDSELA SQATAEFEKAMKELAEEEPH LVEQFQKLSEAAGRVGSDMT SQQEFTSCLKETLSGLAKNA TDLQNSSMSEEELTKAMEGL GMDEGDGEGNILPIMQSIMQ NLLSKDVLYPSLKEITEKYP EWLQSHRESLPPEQFEKYQE QHSVMCKICEQFEAETPTD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human PEX19 (NP_002848.1). |
| Tissue Specificity | Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. |
| Function | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. |
| Protein Name | Peroxisomal Biogenesis Factor 1933 Kda Housekeeping ProteinPeroxin-19Peroxisomal Farnesylated Protein |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-9603798 |
| Cellular Localisation | CytoplasmPeroxisome MembraneLipid-AnchorCytoplasmic SideMainly CytoplasmicSome Fraction Membrane-Associated To The Outer Surface Of Peroxisomes |
| Alternative Antibody Names | Anti-Peroxisomal Biogenesis Factor 19 antibodyAnti-33 Kda Housekeeping Protein antibodyAnti-Peroxin-19 antibodyAnti-Peroxisomal Farnesylated Protein antibodyAnti-PEX19 antibodyAnti-HK33 antibodyAnti-PXF antibodyAnti-OK antibodyAnti-SW-cl.22 antibody |
Information sourced from Uniprot.org
