![Anti-Peroxiredoxin 2/PRP antibody [SM0428] (STJA0010428)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180325/404000/STJA0010428_1__61134.1738950963.png?c=1 "Anti-Peroxiredoxin 2/PRP antibody [SM0428] (STJA0010428)")
![Anti-Peroxiredoxin 2/PRP antibody [SM0428] (STJA0010428)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180325/404000/STJA0010428_1__61134.1738950963.png?c=1 "Anti-Peroxiredoxin 2/PRP antibody [SM0428] (STJA0010428)")
Anti-Peroxiredoxin 2/PRP antibody [SM0428] (STJA0010428)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse PRP
General Information
| Short Description | Mouse monoclonal anti-Peroxiredoxin 2/PRP for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM0428 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (H, M) 1:500-1:1000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Prdx2 |
| Gene ID | 21672 |
| Uniprot ID | PRDX2_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse PRP |
Additional Info
| Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. Acetylation increases resistance to transition to high molecular-mass complexes. Deacetylated by HDAC6 which decreases reducing activity. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). |
| Protein Name | Peroxiredoxin-2Thiol-Specific Antioxidant ProteinTsaThioredoxin Peroxidase 1Thioredoxin-Dependent Peroxide Reductase 1Thioredoxin-Dependent Peroxiredoxin 2 |
| Database Links | Reactome: R-MMU-3299685Reactome: -MMU-5628897 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Peroxiredoxin-2 antibodyAnti-Thiol-Specific Antioxidant Protein antibodyAnti-Tsa antibodyAnti-Thioredoxin Peroxidase 1 antibodyAnti-Thioredoxin-Dependent Peroxide Reductase 1 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 2 antibodyAnti-Prdx2 antibodyAnti-Tdpx1 antibodyAnti-Tpx antibody |
Information sourced from Uniprot.org