| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDGFC (166-345) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDGFC |
| Gene ID: |
56034 |
| Uniprot ID: |
PDGFC_HUMAN |
| Immunogen Region: |
166-345 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 166-345 of human PDGFC (NP_057289.1). |
| Immunogen Sequence: |
QFTEAVSPSVLPPSALPLDL LNNAITAFSTLEDLIRYLEP ERWQLDLEDLYRPTWQLLGK AFVFGRKSRVVDLNLLTEEV RLYSCTPRNFSVSIREELKR TDTIFWPGCLLVKRCGGNCA CCLHNCNECQCVPSKVTKKY HEVLQLRPKTGVRGLHKSLT DVALEHHEECDCVCRGSTGG |
| Tissue Specificity | Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes. |
| Post Translational Modifications | Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG. Sumoylated with SUMO1. N-glycosylated. |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. |
| Protein Name | Platelet-Derived Growth Factor CPdgf-CFalloteinSpinal Cord-Derived Growth FactorScdgfVegf-E Cleaved Into - Platelet-Derived Growth Factor C - Latent FormPdgfc Latent Form - Platelet-Derived Growth Factor C - Receptor-Binding FormPdgfc Receptor-Binding Form |
| Database Links | Reactome: R-HSA-186797 Q9NRA1-1 |
| Cellular Localisation | CytoplasmCytosolSecretedNucleusCytoplasmic GranuleCell MembraneSumoylated Form Is Predominant In The NucleusStored In Alpha Granules In Platelets |
| Alternative Antibody Names | Anti-Platelet-Derived Growth Factor C antibodyAnti-Pdgf-C antibodyAnti-Fallotein antibodyAnti-Spinal Cord-Derived Growth Factor antibodyAnti-Scdgf antibodyAnti-Vegf-E Cleaved Into - Platelet-Derived Growth Factor C - Latent Form antibodyAnti-Pdgfc Latent Form - Platelet-Derived Growth Factor C - Receptor-Binding Form antibodyAnti-Pdgfc Receptor-Binding Form antibodyAnti-PDGFC antibodyAnti-SCDGF antibodyAnti-UNQ174 antibodyAnti-PRO200 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
