Anti-PDE6B antibody (1-190) (STJ29022)

Name: Anti-PDE6B antibody (1-190) (STJ29022)
SKU: STJ29022
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ29022

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Short Description	Rabbit polyclonal PDE6B (1-190) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	PDE6B
Gene ID	5158
Uniprot ID	PDE6B_HUMAN
Immunogen Region	1-190
Immunogen Sequence	MSLSEEQARSFLDQNPDFAR QYFGKKLSPENVAAACEDGC PPDCDSLRDLCQVEESTALL ELVQDMQESINMERVVFKVL RRLCTLLQADRCSLFMYRQR NGVAELATRLFSVQPDSVLE DCLVPPDSEIVFPLDIGVVG HVAQTKKMVNVEDVAECPHF SSFADELTDYKTKNMLATPI MNGKDVVAVI
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PDE6B (NP_001138763.1).

Function	Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP. Necessary for the formation of a functional phosphodiesterase holoenzyme. Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock. May participate in processes of transmission and amplification of the visual signal.
Protein Name	Rod Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase Subunit Beta Gmp-Pde Beta
Database Links	Reactome: R-HSA-2485179 Reactome: R-HSA-2514859 Reactome: R-HSA-4086398
Cellular Localisation	Membrane Lipid-Anchor Cell Projection Cilium Photoreceptor Outer Segment
Alternative Antibody Names	Anti-Rod Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase Subunit Beta antibody Anti-Gmp-Pde Beta antibody Anti-PDE6B antibody Anti-PDEB antibody

Information sourced from Uniprot.org