| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE6B |
| Gene ID: | 5158 |
| Uniprot ID: | PDE6B_HUMAN |
| Immunogen Region: | 1-190 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PDE6B (NP_001138763.1). |
| Immunogen Sequence: | MSLSEEQARSFLDQNPDFAR QYFGKKLSPENVAAACEDGC PPDCDSLRDLCQVEESTALL ELVQDMQESINMERVVFKVL RRLCTLLQADRCSLFMYRQR NGVAELATRLFSVQPDSVLE DCLVPPDSEIVFPLDIGVVG HVAQTKKMVNVEDVAECPHF SSFADELTDYKTKNMLATPI MNGKDVVAVI |
| Function | Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP. Necessary for the formation of a functional phosphodiesterase holoenzyme. Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock. May participate in processes of transmission and amplification of the visual signal. |
| Protein Name | Rod Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase Subunit BetaGmp-Pde Beta |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859Reactome: R-HSA-4086398 |
| Cellular Localisation | MembraneLipid-AnchorCell ProjectionCiliumPhotoreceptor Outer Segment |
| Alternative Antibody Names | Anti-Rod Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase Subunit Beta antibodyAnti-Gmp-Pde Beta antibodyAnti-PDE6B antibodyAnti-PDEB antibody |
Information sourced from Uniprot.org