Anti-PDE3A antibody (380-660) (STJ119906)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PDE3A (380-660) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE3A |
| Gene ID | 5139 |
| Uniprot ID | PDE3A_HUMAN |
| Immunogen Region | 380-660 |
| Immunogen Sequence | LLSTQLTFQAIHKPRVNPVT SLSENYTCSDSEESSEKDKL AIPKRLRRSLPPGLLRRVSS TWTTTTSATGLPTLEPAPVR RDRSTSIKLQEAPSSSPDSW NNPVMMTLTKSRSFTSSYAI SAANHVKAKKQSRPGALAKI SPLSSPCSSPLQGTPASSLV SKISAVQFPESADTTAKQSL GSHRALTYTQSAPDLSPQIL TPPVICSSCGRPYSQGNPAD EPLERSGVATRTPSRTDDT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 380-660 of human PDE3A (NP_000912.3). |
Additional Info
| Function | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Also has activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. |
| Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3aCyclic Gmp-Inhibited Phosphodiesterase ACgi-Pde ACgmp-Inhibited Camp PhosphodiesteraseCgi-Pde |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytosol |
| Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibodyAnti-Cyclic Gmp-Inhibited Phosphodiesterase A antibodyAnti-Cgi-Pde A antibodyAnti-Cgmp-Inhibited Camp Phosphodiesterase antibodyAnti-Cgi-Pde antibodyAnti-PDE3A antibody |
Information sourced from Uniprot.org