Anti-PDE11A antibody (Internal) (STJ71246)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PDE11A (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 60-65kDa band observed in Human Skeletal Muscle and Human Prostate lysates (calculated MW of 65.7kDa according to NP_001070826.1). Recommended concentration: 0.5-1.5µg/ml.IH |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE11A |
| Gene ID | 50940 |
| Uniprot ID | PDE11_HUMAN |
| Accession Number | NP_058649.3 ; NP_001070665.1; NP_001070826.1; NP_001070664.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | NSFKESMEKSSYSD |
| Specificity | This antibody is expected to recognise all four reported isoforms (NP_058649.3 ; NP_001070665.1; NP_001070826.1; NP_001070664.1). |
Additional Info
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. |
| Protein Name | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11aCamp And Cgmp Phosphodiesterase 11a |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a antibodyAnti-Camp And Cgmp Phosphodiesterase 11a antibodyAnti-PDE11A antibody |
Information sourced from Uniprot.org