Anti-PCSK6 antibody (Internal) (STJ71714)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PCSK6 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave an approx 40-45 kDa band in Human Brain (Cerebellum) lysates after 0.2 µg/ml antibody staining. Please note that currently we cannot find an explanation in |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PCSK6 |
| Gene ID | 5046 |
| Uniprot ID | PCSK6_HUMAN |
| Accession Number | NP_002561.1; NP_612192.1; NP_612195.1; NP_612197.1; NP_612196.1; NP_612198.2; NP_612193.1; NP_612194.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | YHTFSAHQSRSR |
| Specificity | This antibody is expected to recognize reported isoforms a, b, g and h (NP_002561.1; NP_612192.1; NP_612193.1; NP_612194.1 resp.). |
Additional Info
| Function | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXXKRR consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. |
| Protein Name | Proprotein Convertase Subtilisin/Kexin Type 6Paired Basic Amino Acid Cleaving Enzyme 4Subtilisin-Like Proprotein Convertase 4Spc4Subtilisin/Kexin-Like Protease Pace4 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-167060Reactome: R-HSA-6809371Reactome: R-HSA-8963889 |
| Cellular Localisation | Isoform Pace4a-I: SecretedIsoform Pace4a-Ii: SecretedIsoform Pace4c: Endoplasmic ReticulumNot SecretedRemains Probably In Zymogen Form In Endoplasmic ReticulumIsoform Pace4cs: Endoplasmic ReticulumIsoform Pace4e-I: Endomembrane SystemPeripheral Membrane ProteinRetained Intracellularly Probably Through A Hydrophobic Cluster In Their C-TerminusIsoform Pace4e-Ii: Endomembrane SystemIsoform Pace4b: Secreted |
| Alternative Antibody Names | Anti-Proprotein Convertase Subtilisin/Kexin Type 6 antibodyAnti-Paired Basic Amino Acid Cleaving Enzyme 4 antibodyAnti-Subtilisin-Like Proprotein Convertase 4 antibodyAnti-Spc4 antibodyAnti-Subtilisin/Kexin-Like Protease Pace4 antibodyAnti-PCSK6 antibodyAnti-PACE4 antibody |
Information sourced from Uniprot.org