| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PCSK6 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-5µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PCSK6 |
| Gene ID: |
5046 |
| Uniprot ID: |
PCSK6_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_002561.1; NP_612192.1; NP_612195.1; NP_612197.1; NP_612196.1; NP_612198.2; NP_612193.1; NP_612194.1 |
| Specificity: |
This antibody is expected to recognize reported isoforms a, b, g and h (NP_002561.1; NP_612192.1; NP_612193.1; NP_612194.1 resp.). |
| Immunogen Sequence: |
YHTFSAHQSRSR |
| Function | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXXKRR consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. |
| Protein Name | Proprotein Convertase Subtilisin/Kexin Type 6Paired Basic Amino Acid Cleaving Enzyme 4Subtilisin-Like Proprotein Convertase 4Spc4Subtilisin/Kexin-Like Protease Pace4 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-167060Reactome: R-HSA-6809371Reactome: R-HSA-8963889 |
| Cellular Localisation | Isoform Pace4a-I: SecretedIsoform Pace4a-Ii: SecretedIsoform Pace4c: Endoplasmic ReticulumNot SecretedRemains Probably In Zymogen Form In Endoplasmic ReticulumIsoform Pace4cs: Endoplasmic ReticulumIsoform Pace4e-I: Endomembrane SystemPeripheral Membrane ProteinRetained Intracellularly Probably Through A Hydrophobic Cluster In Their C-TerminusIsoform Pace4e-Ii: Endomembrane SystemIsoform Pace4b: Secreted |
| Alternative Antibody Names | Anti-Proprotein Convertase Subtilisin/Kexin Type 6 antibodyAnti-Paired Basic Amino Acid Cleaving Enzyme 4 antibodyAnti-Subtilisin-Like Proprotein Convertase 4 antibodyAnti-Spc4 antibodyAnti-Subtilisin/Kexin-Like Protease Pace4 antibodyAnti-PCSK6 antibodyAnti-PACE4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
