Anti-PCBD1 antibody (1-104) (STJ28475)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PCBD1 (1-104) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PCBD1 |
| Gene ID | 5092 |
| Uniprot ID | PHS_HUMAN |
| Immunogen Region | 1-104 |
| Immunogen Sequence | MAGKAHRLSAEERDQLLPNL RAVGWNELEGRDAIFKQFHF KDFNRAFGFMTRVALQAEKL DHHPEWFNVYNKVHITLSTH ECAGLSERDINLASFIEQVA VSMT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-104 of human PCBD1 (NP_000272.1). |
Additional Info
| Function | Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription. |
| Protein Name | Pterin-4-Alpha-Carbinolamine DehydratasePhs4-Alpha-Hydroxy-Tetrahydropterin DehydrataseDimerization Cofactor Of Hepatocyte Nuclear Factor 1-AlphaDcohDimerization Cofactor Of Hnf1Phenylalanine Hydroxylase-Stimulating ProteinPterin Carbinolamine DehydratasePcd |
| Database Links | Reactome: R-HSA-8964208 |
| Cellular Localisation | CytoplasmNucleusRecruited To The Nucleus Through The Interaction With Hnf1b |
| Alternative Antibody Names | Anti-Pterin-4-Alpha-Carbinolamine Dehydratase antibodyAnti-Phs antibodyAnti-4-Alpha-Hydroxy-Tetrahydropterin Dehydratase antibodyAnti-Dimerization Cofactor Of Hepatocyte Nuclear Factor 1-Alpha antibodyAnti-Dcoh antibodyAnti-Dimerization Cofactor Of Hnf1 antibodyAnti-Phenylalanine Hydroxylase-Stimulating Protein antibodyAnti-Pterin Carbinolamine Dehydratase antibodyAnti-Pcd antibodyAnti-PCBD1 antibodyAnti-DCOH antibodyAnti-PCBD antibody |
Information sourced from Uniprot.org