Host: |
Rabbit |
Applications: |
WB/IF/IP |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-PC (879-1178) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:1000IF/ICC 1:10-1:100IP 1:500-1:1000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
PC |
Gene ID: |
5091 |
Uniprot ID: |
PYC_HUMAN |
Immunogen Region: |
879-1178 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 879-1178 of human Pyruvate carboxylase (Pyruvate carboxylase (PC) ) (NP_001035806.1). |
Immunogen Sequence: |
HSMGLGSKFKEVKKAYVEAN QMLGDLIKVTPSSKIVGDLA QFMVQNGLSRAEAEAQAEEL SFPRSVVEFLQGYIGVPHGG FPEPFRSKVLKDLPRVEGRP GASLPPLDLQALEKELVDRH GEEVTPEDVLSAAMYPDVFA HFKDFTATFGPLDSLNTRLF LQGPKIAEEFEVELERGKTL HIKALAVSDLNRAGQRQVFF ELNGQLRSILVKDTQAMKEM HFHPKALKDVKGQIGAPMP |
Post Translational Modifications | Acetylation of Lys-748 might play a role in catalytic activity regulation. |
Function | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. |
Protein Name | Pyruvate Carboxylase - MitochondrialPyruvic CarboxylasePcb |
Database Links | Reactome: R-HSA-196780Reactome: R-HSA-3371599Reactome: R-HSA-70263 |
Cellular Localisation | Mitochondrion Matrix |
Alternative Antibody Names | Anti-Pyruvate Carboxylase - Mitochondrial antibodyAnti-Pyruvic Carboxylase antibodyAnti-Pcb antibodyAnti-PC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance