Anti-PBK antibody [R07-0B0] (STJA0035316)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human PBK/SPK
General Information
| Short Description | Rabbit monoclonal anti-PBK for use in WB, IHC-P and IP in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-0B0 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PBK |
| Gene ID | 55872 |
| Uniprot ID | TOPK_HUMAN |
| Immunogen | Recombinant protein of human PBK/SPK |
Additional Info
| Tissue Specificity | Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. |
| Post Translational Modifications | Phosphorylated.in a cell-cycle dependent manner at mitosis. |
| Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. |
| Protein Name | Lymphokine-Activated Killer T-Cell-Originated Protein KinaseCancer/Testis Antigen 84Ct84Mapkk-Like Protein KinaseNori-3Pdz-Binding KinaseSpermatogenesis-Related Protein KinaseSpkT-Lak Cell-Originated Protein Kinase |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Lymphokine-Activated Killer T-Cell-Originated Protein Kinase antibodyAnti-Cancer/Testis Antigen 84 antibodyAnti-Ct84 antibodyAnti-Mapkk-Like Protein Kinase antibodyAnti-Nori-3 antibodyAnti-Pdz-Binding Kinase antibodyAnti-Spermatogenesis-Related Protein Kinase antibodyAnti-Spk antibodyAnti-T-Lak Cell-Originated Protein Kinase antibodyAnti-PBK antibodyAnti-TOPK antibody |
Information sourced from Uniprot.org