Anti-PAXX antibody (STJA0008957)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human C9orf142
General Information
| Short Description | Rabbit polyclonal anti-Protein PAXX for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAXX |
| Gene ID | 286257 |
| Uniprot ID | PAXX_HUMAN |
| Immunogen | Synthesized peptide derived from human C9orf142 |
| Specificity | This antibody detects endogenous levels of C9orf142 at Human, Mouse |
Additional Info
| Function | Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ).participates in double-strand break (DSB) repair and V(D)J recombination. May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Involved in NHEJ by promoting the ligation of blunt-ended DNA ends. Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair. Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism. |
| Protein Name | Protein PaxxParalog Of Xrcc4 And XlfXrcc4-Like Small Protein |
| Database Links | |
| Cellular Localisation | NucleusChromosomePredominantly Localizes To The NucleusAccumulates At Sites Of Dna Damage Generated By Laser MicroirradiationCytoplasm(Microbial Infection) Upon Infection By Herpesvirus 1 (Hsv-1)It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Antibody Names | Anti-Protein Paxx antibodyAnti-Paralog Of Xrcc4 And Xlf antibodyAnti-Xrcc4-Like Small Protein antibodyAnti-PAXX antibodyAnti-C9orf142 antibodyAnti-XLS antibody |
Information sourced from Uniprot.org