| Function | Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ).participates in double-strand break (DSB) repair and V(D)J recombination. May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Involved in NHEJ by promoting the ligation of blunt-ended DNA ends. Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair. Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism. |
| Protein Name | Protein PaxxParalog Of Xrcc4 And XlfXrcc4-Like Small Protein |
| Database Links | |
| Cellular Localisation | NucleusChromosomePredominantly Localizes To The NucleusAccumulates At Sites Of Dna Damage Generated By Laser MicroirradiationCytoplasm(Microbial Infection) Upon Infection By Herpesvirus 1 (Hsv-1)It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Antibody Names | Anti-Protein Paxx antibodyAnti-Paralog Of Xrcc4 And Xlf antibodyAnti-Xrcc4-Like Small Protein antibodyAnti-PAXX antibodyAnti-C9orf142 antibodyAnti-XLS antibody |
Information sourced from Uniprot.org
