| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein mono-ADP-ribosyltransferase PARP10 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PARP10 |
| Gene ID: |
84875 |
| Uniprot ID: |
PAR10_HUMAN |
| Specificity: |
PAR10 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. Auto-mono-ADP-ribosylated on glutamate and lysine residues. |
| Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp10Adp-Ribosyltransferase Diphtheria Toxin-Like 10Artd10Poly Adp-Ribose Polymerase 10Parp-10 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-9683610Reactome: R-HSA-9694631 |
| Cellular Localisation | NucleusNucleolusCytoplasmShuttles Between The Nuclear And Cytoplasmic CompartmentA Subpopulation Concentrates In The Nucleolus During Late G1/S Phase |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp10 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 10 antibodyAnti-Artd10 antibodyAnti-Poly Adp-Ribose Polymerase 10 antibodyAnti-Parp-10 antibodyAnti-PARP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
