Anti-PARP10 antibody (STJ192239)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Protein mono-ADP-ribosyltransferase PARP10 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARP10 |
| Gene ID | 84875 |
| Uniprot ID | PAR10_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PAR10 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. Auto-mono-ADP-ribosylated on glutamate and lysine residues. |
| Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp10Adp-Ribosyltransferase Diphtheria Toxin-Like 10Artd10Poly Adp-Ribose Polymerase 10Parp-10 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-9683610Reactome: R-HSA-9694631 |
| Cellular Localisation | NucleusNucleolusCytoplasmShuttles Between The Nuclear And Cytoplasmic CompartmentA Subpopulation Concentrates In The Nucleolus During Late G1/S Phase |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp10 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 10 antibodyAnti-Artd10 antibodyAnti-Poly Adp-Ribose Polymerase 10 antibodyAnti-Parp-10 antibodyAnti-PARP10 antibody |
Information sourced from Uniprot.org