| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PANK2 (300-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PANK2 |
| Gene ID: |
80025 |
| Uniprot ID: |
PANK2_HUMAN |
| Immunogen Region: |
300-400 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_705902.2). |
| Immunogen Sequence: |
RDKNFSSLHTVFCATGGGAY KFEQDFLTIGDLQLCKLDEL DCLIKGILYIDSVGFNGRSQ CYYFENPADSEKCQKLPFDL KNPYPLLLVNIGSGVSILAV Y |
| Tissue Specificity | Expressed in the brain (at protein level). Ubiquitous. Highly expressed in the testis. Expressed in the umbilical vein endothelial cells (HUVEC). |
| Post Translational Modifications | Synthesized as a 62-kDa precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 59-kDa intermediate to yield the mature mitochondrial 48-kDa subunit. |
| Function | Isoform 1: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC). Isoform 4: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. |
| Protein Name | Pantothenate Kinase 2 - MitochondrialHpank2Pantothenic Acid Kinase 2 Cleaved Into - Pantothenate Kinase 2 - Mitochondrial Intermediate FormIpank2 - Pantothenate Kinase 2 - Mitochondrial Mature FormMpank2 |
| Database Links | Reactome: R-HSA-196783 |
| Cellular Localisation | Isoform 1: MitochondrionMitochondrion Intermembrane SpaceNucleusLocalizes Predominantly To The Mitochondria And To A Lesser Extent To The NucleusFound In Both The Mitochondria And The Nucleus Throughout The Cell CycleWith The Exception Of The G2/M Phase When It Is Restricted To MitochdondriaIsoform 2: CytoplasmIsoform 3: CytoplasmIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-Pantothenate Kinase 2 - Mitochondrial antibodyAnti-Hpank2 antibodyAnti-Pantothenic Acid Kinase 2 Cleaved Into - Pantothenate Kinase 2 - Mitochondrial Intermediate Form antibodyAnti-Ipank2 - Pantothenate Kinase 2 - Mitochondrial Mature Form antibodyAnti-Mpank2 antibodyAnti-PANK2 antibodyAnti-C20orf48 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
