| Tissue Specificity | Expressed in the brain (at protein level). Ubiquitous. Highly expressed in the testis. Expressed in the umbilical vein endothelial cells (HUVEC). |
| Post Translational Modifications | Synthesized as a 62-kDa precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 59-kDa intermediate to yield the mature mitochondrial 48-kDa subunit. |
| Function | Isoform 1: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC). Isoform 4: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. |
| Protein Name | Pantothenate Kinase 2 - MitochondrialHpank2Pantothenic Acid Kinase 2 Cleaved Into - Pantothenate Kinase 2 - Mitochondrial Intermediate FormIpank2 - Pantothenate Kinase 2 - Mitochondrial Mature FormMpank2 |
| Database Links | Reactome: R-HSA-196783 |
| Cellular Localisation | Isoform 1: MitochondrionMitochondrion Intermembrane SpaceNucleusLocalizes Predominantly To The Mitochondria And To A Lesser Extent To The NucleusFound In Both The Mitochondria And The Nucleus Throughout The Cell CycleWith The Exception Of The G2/M Phase When It Is Restricted To MitochdondriaIsoform 2: CytoplasmIsoform 3: CytoplasmIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-Pantothenate Kinase 2 - Mitochondrial antibodyAnti-Hpank2 antibodyAnti-Pantothenic Acid Kinase 2 Cleaved Into - Pantothenate Kinase 2 - Mitochondrial Intermediate Form antibodyAnti-Ipank2 - Pantothenate Kinase 2 - Mitochondrial Mature Form antibodyAnti-Mpank2 antibodyAnti-PANK2 antibodyAnti-C20orf48 antibody |
Information sourced from Uniprot.org
