| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pan-Voltage-dependent L-type calcium channel subunit alpha-1C (1288-1338 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA1C |
| Gene ID: |
775 |
| Uniprot ID: |
CAC1C_HUMAN |
| Immunogen Region: |
1288-1338 aa |
| Specificity: |
Cav pan Alpha 1 protein (A211) detects endogenous levels of Cav pan Alpha 1 |
| Immunogen: |
Synthetic peptide derived from Cav pan Alpha 1 at the amino acid range 1288-1338 |
| Post Translational Modifications | Phosphorylation by PKA at Ser-1981 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA. |
| Function | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1cCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac MuscleVoltage-Gated Calcium Channel Subunit Alpha Cav1.2 |
| Database Links | Reactome: R-HSA-400042Reactome: R-HSA-419037Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaPerikaryonPostsynaptic Density MembraneCell ProjectionDendriteT-TubuleColocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional MembraneWhere The Sarcolemma And The Sarcoplasmic Reticulum Are In Close ContactThe Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 antibodyAnti-CACNA1C antibodyAnti-CACH2 antibodyAnti-CACN2 antibodyAnti-CACNL1A1 antibodyAnti-CCHL1A1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
