• Anti-PAG/Cbp antibody [MEM-255] (STJ16100482)

Anti-PAG/Cbp antibody [MEM-255] (STJ16100482)

SKU:
STJ16100482-01

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Host: Mouse
Applications: FC/WB/IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-PAG/Cbp is suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: MEM-255
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CREBBP
Gene ID: 1387
Uniprot ID: CBP_HUMAN
Immunogen: Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
Post Translational Modifications Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386.these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53. Autoacetylation is induced by glucose and fatty acids.
Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Acetylates PCNA.acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway.
Protein Name Creb-Binding Protein
Histone Lysine Acetyltransferase Crebbp
Protein-Lysine Acetyltransferase Crebbp
Database Links Reactome: R-HSA-1234158
Reactome: R-HSA-1368082
Reactome: R-HSA-1368108
Reactome: R-HSA-1912408
Reactome: R-HSA-1989781
Reactome: R-HSA-201722
Reactome: R-HSA-210744
Reactome: R-HSA-2122947
Reactome: R-HSA-2151201
Reactome: R-HSA-2426168
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-3134973
Reactome: R-HSA-3214847
Reactome: R-HSA-3371568
Reactome: R-HSA-350054
Reactome: R-HSA-381340
Reactome: R-HSA-3899300
Reactome: R-HSA-400206
Reactome: R-HSA-400253
Reactome: R-HSA-5617472
Reactome: R-HSA-5621575
Reactome: R-HSA-6803204
Reactome: R-HSA-8866907
Reactome: R-HSA-8939246
Reactome: R-HSA-8941856
Reactome: R-HSA-9013508
Reactome: R-HSA-9013695
Reactome: R-HSA-9018519
Reactome: R-HSA-918233
Reactome: R-HSA-933541
Reactome: R-HSA-9614657
Reactome: R-HSA-9617629
Reactome: R-HSA-9705671
Reactome: R-HSA-9707564
Reactome: R-HSA-9707616
Reactome: R-HSA-9759194
Reactome: R-HSA-9768919
Reactome: R-HSA-9793380
Reactome: R-HSA-9818027
Reactome: R-HSA-9818028
Cellular Localisation Cytoplasm
Nucleus
Recruited To Nuclear Bodies By Ss18l1/Crest
In The Presence Of Alx1 Relocalizes From The Cytoplasm To The Nucleus
Alternative Antibody Names Anti-Creb-Binding Protein antibody
Anti-Histone Lysine Acetyltransferase Crebbp antibody
Anti-Protein-Lysine Acetyltransferase Crebbp antibody
Anti-CREBBP antibody
Anti-CBP antibody

Information sourced from Uniprot.org

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