| Host: |
Mouse |
| Applications: |
FC/WB/IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-PAG/Cbp is suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
MEM-255 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
CREBBP |
| Gene ID: |
1387 |
| Uniprot ID: |
CBP_HUMAN |
| Immunogen: |
Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG). |
| Post Translational Modifications | Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386.these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B. Phosphorylated by _ at Ser-124 in response to DNA damage, promoting interaction with MRE11 and lactylation of MRE11. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53. Autoacetylation is induced by glucose and fatty acids. |
| Function | Acetylates histones, giving a specific tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Acetylates PCNA.acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation. Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway. |
| Protein Name | Creb-Binding ProteinHistone Lysine Acetyltransferase CrebbpProtein Lactyltransferas CrebbpProtein-Lysine Acetyltransferase Crebbp |
| Database Links | Reactome: R-HSA-1234158Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1912408Reactome: R-HSA-1989781Reactome: R-HSA-201722Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3134973Reactome: R-HSA-3214847Reactome: R-HSA-3371568Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-5617472Reactome: R-HSA-5621575Reactome: R-HSA-6803204Reactome: R-HSA-8866907Reactome: R-HSA-8939246Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9018519Reactome: R-HSA-918233Reactome: R-HSA-933541Reactome: R-HSA-9614657Reactome: R-HSA-9617629Reactome: R-HSA-9705671Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9759194Reactome: R-HSA-9768919Reactome: R-HSA-9793380Reactome: R-HSA-9818026Reactome: R-HSA-9818027Reactome: R-HSA-9818028Reactome: R-HSA-9818030Reactome: R-HSA-9818032Reactome: R-HSA-9818035Reactome: R-HSA-9818749Reactome: R-HSA-9819196Reactome: R-HSA-9833109Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmNucleusRecruited To Nuclear Bodies By Ss18l1/CrestIn The Presence Of Alx1 Relocalizes From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Creb-Binding Protein antibodyAnti-Histone Lysine Acetyltransferase Crebbp antibodyAnti-Protein Lactyltransferas Crebbp antibodyAnti-Protein-Lysine Acetyltransferase Crebbp antibodyAnti-CREBBP antibodyAnti-CBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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