| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-P2RY4 (4th Cytoplasmic Domain) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | P2ry4 |
| Gene ID: | 57385 |
| Uniprot ID: | P2RY4_MOUSE |
| Immunogen Region: | 4th Cytoplasmic Domain |
| Specificity: | Specific for P2RY4. |
| Immunogen: | A synthetic peptide from the 4th cytoplasmic domain of mouse P2Y4 (P2RY4) conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylation of Ser-329 and Ser-330 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium-activated kinases. |
| Function | Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Name | P2y Purinoceptor 4P2y4 |
| Database Links | Reactome: R-MMU-417957Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-P2y Purinoceptor 4 antibodyAnti-P2y4 antibodyAnti-P2ry4 antibodyAnti-P2y4r antibody |
Information sourced from Uniprot.org