| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OSBPL8 |
| Gene ID: |
114882 |
| Uniprot ID: |
OSBL8_HUMAN |
| Immunogen Region: |
1-110 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OSBPL8 (NP_065892.1). |
| Immunogen Sequence: |
MEGGLADGEPDRTSLLGDSK DVLGPSTVVANSDESQLLTP GKMSQRQGKEAYPTPTKDLH QPSLSPASPHSQGFERGKED ISQNKDESSLSMSKSKSESK LYNGSEKDSS |
| Tissue Specificity | Widely expressed. Expressed at higher level in macrophages. |
| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 8Orp-8Osbp-Related Protein 8 |
| Database Links | Reactome: R-HSA-1482801 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneThe Presence Of The N-Terminus Extension Contains An Overall Negative Charge That May Explain The Weak Localization To The Cortical Endoplasmic Reticulum (Probable)Isoform 3: Endoplasmic Reticulum MembraneLocalizes To The Cortical Endoplasmic Reticulum At The Endoplasmic Reticulum-Plasma Membrane Contact Sites |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 8 antibodyAnti-Orp-8 antibodyAnti-Osbp-Related Protein 8 antibodyAnti-OSBPL8 antibodyAnti-KIAA1451 antibodyAnti-ORP8 antibodyAnti-OSBP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
