Anti-OSBPL8 antibody (1-110) (STJ119841)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OSBPL8 (1-110) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OSBPL8 |
| Gene ID | 114882 |
| Uniprot ID | OSBL8_HUMAN |
| Immunogen Region | 1-110 |
| Immunogen Sequence | MEGGLADGEPDRTSLLGDSK DVLGPSTVVANSDESQLLTP GKMSQRQGKEAYPTPTKDLH QPSLSPASPHSQGFERGKED ISQNKDESSLSMSKSKSESK LYNGSEKDSS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OSBPL8 (NP_065892.1). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed at higher level in macrophages. |
| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 8Orp-8Osbp-Related Protein 8 |
| Database Links | Reactome: R-HSA-1482801 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneThe Presence Of The N-Terminus Extension Contains An Overall Negative Charge That May Explain The Weak Localization To The Cortical Endoplasmic Reticulum (Probable)Isoform 3: Endoplasmic Reticulum MembraneLocalizes To The Cortical Endoplasmic Reticulum At The Endoplasmic Reticulum-Plasma Membrane Contact Sites |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 8 antibodyAnti-Orp-8 antibodyAnti-Osbp-Related Protein 8 antibodyAnti-OSBPL8 antibodyAnti-KIAA1451 antibodyAnti-ORP8 antibodyAnti-OSBP10 antibody |
Information sourced from Uniprot.org