Immunohistochemistry analysis of OSBPL8 in paraffin-embedded Human esophageal using OSBPL8 Rabbit polyclonal antibody (STJ119841) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-OSBPL8 antibody (1-110) (STJ119841)

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STJ119841
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OSBPL8
Gene ID: 114882
Uniprot ID: OSBL8_HUMAN
Immunogen Region: 1-110
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OSBPL8 (NP_065892.1).
Immunogen Sequence: MEGGLADGEPDRTSLLGDSK DVLGPSTVVANSDESQLLTP GKMSQRQGKEAYPTPTKDLH QPSLSPASPHSQGFERGKED ISQNKDESSLSMSKSKSESK LYNGSEKDSS
Tissue Specificity Widely expressed. Expressed at higher level in macrophages.
Function Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol.
Protein Name Oxysterol-Binding Protein-Related Protein 8
Orp-8
Osbp-Related Protein 8
Database Links Reactome: R-HSA-1482801
Cellular Localisation Isoform 1: Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Nucleus Membrane
The Presence Of The N-Terminus Extension Contains An Overall Negative Charge That May Explain The Weak Localization To The Cortical Endoplasmic Reticulum (Probable)
Isoform 3: Endoplasmic Reticulum Membrane
Localizes To The Cortical Endoplasmic Reticulum At The Endoplasmic Reticulum-Plasma Membrane Contact Sites
Alternative Antibody Names Anti-Oxysterol-Binding Protein-Related Protein 8 antibody
Anti-Orp-8 antibody
Anti-Osbp-Related Protein 8 antibody
Anti-OSBPL8 antibody
Anti-KIAA1451 antibody
Anti-ORP8 antibody
Anti-OSBP10 antibody

Information sourced from Uniprot.org

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