Anti-OSBPL8 antibody (290-340 aa) (STJ194867)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human OSBL8 at the amino acid range 290-340
General Information
| Short Description | Rabbit polyclonal anti-Oxysterol-binding protein-related protein 8 (290-340 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OSBPL8 |
| Gene ID | 114882 |
| Uniprot ID | OSBL8_HUMAN |
| Immunogen | Synthesized peptide derived from the human OSBL8 at the amino acid range 290-340 |
| Immunogen Region | 290-340 aa |
| Specificity | This antibody detects endogenous levels of OSBL8 at Human |
Additional Info
| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 8Orp-8Osbp-Related Protein 8 |
| Database Links | Reactome: R-HSA-1482801 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneThe Presence Of The N-Terminus Extension Contains An Overall Negative Charge That May Explain The Weak Localization To The Cortical Endoplasmic Reticulum (Probable)Isoform 3: Endoplasmic Reticulum MembraneLocalizes To The Cortical Endoplasmic Reticulum At The Endoplasmic Reticulum-Plasma Membrane Contact Sites |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 8 antibodyAnti-Orp-8 antibodyAnti-Osbp-Related Protein 8 antibodyAnti-OSBPL8 antibodyAnti-KIAA1451 antibodyAnti-ORP8 antibodyAnti-OSBP10 antibody |
Information sourced from Uniprot.org