| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ORP2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 55-60kDa band observed in Human Heart lysates (predicted MWs of 54 and 55kDa according to NP_055650.1 and NP_653081.1). Recommended for use at 1-2µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | OSBPL2 |
| Gene ID: | 9885 |
| Uniprot ID: | OSBL2_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_055650.1; NP_653081.1 |
| Specificity: | This antibody is expected to recognise both reported isoforms (represented by NP_055650.1 and NP_653081.1) |
| Immunogen Sequence: | YFERNFSDCPDIY |
| Function | Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). |
| Protein Name | Oxysterol-Binding Protein-Related Protein 2Orp-2Osbp-Related Protein 2 |
| Database Links | Reactome: R-HSA-192105 |
| Cellular Localisation | CytoplasmCytosolLipid DropletCell MembranePeripheral Membrane ProteinCytoplasmic SideDetected On The Surface Of Cytosolic Lipid DropletsRecruited To The Cell Membrane By Phosphatidylinositol-Phosphate Binding |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 2 antibodyAnti-Orp-2 antibodyAnti-Osbp-Related Protein 2 antibodyAnti-OSBPL2 antibodyAnti-KIAA0772 antibodyAnti-ORP2 antibody |
Information sourced from Uniprot.org
