Anti-OAS2 antibody (Internal) (STJ73371)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-OAS2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 85 +19kDa bands observed in lysates of cell line Jurkat (calculated MW of 82.4kDa according to NP_058197.2 and of 19.5kDa according to NP_001027903.1). Recommended concentratio |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | OAS2 |
| Gene ID | 4939 |
| Uniprot ID | OAS2_HUMAN |
| Accession Number | NP_058197.2; NP_002526.2; NP_001027903.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | RKTVLRGNSDGT |
| Specificity | This antibody is expected to recognize all reported isoforms (NP_058197.2; NP_002526.2; NP_001027903.1). |
Additional Info
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection. |
| Protein Name | 2'-5'-Oligoadenylate Synthase 2(2-5'Oligo(A Synthase 22-5a Synthase 2P69 Oas / P71 OasP69oas / P71oas |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-8983711Reactome: R-HSA-909733Reactome: R-HSA-9833110 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-2'-5'-Oligoadenylate Synthase 2 antibodyAnti-(2-5'Oligo(A Synthase 2 antibodyAnti-2-5a Synthase 2 antibodyAnti-P69 Oas / P71 Oas antibodyAnti-P69oas / P71oas antibodyAnti-OAS2 antibody |
Information sourced from Uniprot.org