• STJ73371 (1µg/ml) staining of Jurkat lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OAS2 antibody (Internal) (STJ73371)

SKU:
STJ73371-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-OAS2 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: OAS2
Gene ID: 4939
Uniprot ID: OAS2_HUMAN
Immunogen Region: Internal
Accession Number: NP_058197.2; NP_002526.2; NP_001027903.1
Specificity: This antibody is expected to recognize all reported isoforms (NP_058197.2; NP_002526.2; NP_001027903.1).
Immunogen Sequence: RKTVLRGNSDGT
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection.
Protein Name 2'-5'-Oligoadenylate Synthase 2
(2-5'Oligo(A Synthase 2
2-5a Synthase 2
P69 Oas / P71 Oas
P69oas / P71oas
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-8983711
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative Antibody Names Anti-2'-5'-Oligoadenylate Synthase 2 antibody
Anti-(2-5'Oligo(A Synthase 2 antibody
Anti-2-5a Synthase 2 antibody
Anti-P69 Oas / P71 Oas antibody
Anti-P69oas / P71oas antibody
Anti-OAS2 antibody

Information sourced from Uniprot.org

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