| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-OAS2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000. WB: Approx 85 +19kDa bands observed in lysates of cell line Jurkat (calculated MW of 82.4kDa according to NP_058197.2 and of 19.5kDa according to NP_001027903.1). Recommended concentratio |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | OAS2 |
| Gene ID: | 4939 |
| Uniprot ID: | OAS2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_058197.2; NP_002526.2; NP_001027903.1 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_058197.2; NP_002526.2; NP_001027903.1). |
| Immunogen Sequence: | RKTVLRGNSDGT |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection. |
| Protein Name | 2'-5'-Oligoadenylate Synthase 2 (2-5'Oligo(A Synthase 2 2-5a Synthase 2 P69 Oas / P71 Oas P69oas / P71oas |
| Database Links | Reactome: R-HSA-877300 Reactome: R-HSA-8983711 Reactome: R-HSA-909733 Reactome: R-HSA-9833110 |
| Cellular Localisation | Cytoplasm Perinuclear Region |
| Alternative Antibody Names | Anti-2'-5'-Oligoadenylate Synthase 2 antibody Anti-(2-5'Oligo(A Synthase 2 antibody Anti-2-5a Synthase 2 antibody Anti-P69 Oas / P71 Oas antibody Anti-P69oas / P71oas antibody Anti-OAS2 antibody |
Information sourced from Uniprot.org