Anti-NXN antibody (100-280) (STJ11102879)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NXN (100-280) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NXN |
| Gene ID | 64359 |
| Uniprot ID | NXN_HUMAN |
| Immunogen Region | 100-280 |
| Immunogen Sequence | CRSLTRVLVESYRKIKEAGQ NFEIIFVSADRSEESFKQYF SEMPWLAVPYTDEARRSRLN RLYGIQGIPTLIMLDPQGEV ITRQGRVEVLNDEDCREFPW HPKPVLELSDSNAAQLNEGP CLVLFVDSEDDGESEAAKQL IQPIAEKIIAKYKAKEEEAP LLFFVAGEDDMTDSLRDYTN L |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human NXN (NP_001192248.1). |
Additional Info
| Function | Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). |
| Protein Name | Nucleoredoxin |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-Nucleoredoxin antibodyAnti-NXN antibodyAnti-NRX antibody |
Information sourced from Uniprot.org