Anti-NUDT15 antibody (1-164) (STJ116076)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NUDT15 (1-164) antibody for use in WB, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUDT15 |
| Gene ID | 55270 |
| Uniprot ID | NUD15_HUMAN |
| Immunogen Region | 1-164 |
| Immunogen Sequence | MTASAQPRGRRPGVGVGVVV TSCKHPRCVLLGKRKGSVGA GSFQLPGGHLEFGETWEECA QRETWEEAALHLKNVHFASV VNSFIEKENYHYVTILMKGE VDVTHDSEPKNVEPEKNESW EWVPWEELPPLDQLFWGLRC LKEQGYDPFKEDLNHLVGYK GNHL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1). |
Additional Info
| Function | May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro. |
| Protein Name | Nucleotide Triphosphate Diphosphatase Nudt15Mutt Homolog 2Mth2Nucleoside Diphosphate-Linked Moiety X Motif 15Nudix Motif 15Nucleoside Diphosphate-Linked To Another Moiety X Hydrolase 15Nudix Hydrolase 15 |
| Database Links | Reactome: R-HSA-2393930Reactome: R-HSA-9748787 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nucleotide Triphosphate Diphosphatase Nudt15 antibodyAnti-Mutt Homolog 2 antibodyAnti-Mth2 antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 15 antibodyAnti-Nudix Motif 15 antibodyAnti-Nucleoside Diphosphate-Linked To Another Moiety X Hydrolase 15 antibodyAnti-Nudix Hydrolase 15 antibodyAnti-NUDT15 antibodyAnti-MTH2 antibody |
Information sourced from Uniprot.org