Anti-NUDT1/MTH1 antibody (1-156aa) [AT3B3] (STJA0041750)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human NUDT1 (1-156aa) purified from E. coli.
General Information
| Short Description | Mouse monoclonal anti-NUDT1/MTH1 (1-156aa) for use in ELISA, WB, ICC, IF and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF/FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT3B3 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUDT1 |
| Gene ID | 4521 |
| Uniprot ID | 8ODP_HUMAN |
| Accession Number | NP_945191 |
| Immunogen | Recombinant human NUDT1 (1-156aa) purified from E. coli. |
| Immunogen Region | 1-156aa |
Additional Info
| Tissue Specificity | Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress. |
| Protein Name | Oxidized Purine Nucleoside Triphosphate Hydrolase2-Hydroxy-Datp Diphosphatase7 -8-Dihydro-8-Oxoguanine Triphosphatase8-Oxo-DgtpaseMethylated Purine Nucleoside Triphosphate HydrolaseNucleoside Diphosphate-Linked Moiety X Motif 1Nudix Motif 1 |
| Database Links | Reactome: R-HSA-2393930 |
| Cellular Localisation | Isoform P18: CytoplasmCytosolMitochondrion MatrixNucleusMostly Present In CytosolA Minor Proportion Is MitochondrialA Very Small Amount Of The Protein Is Associated With NucleiIsoform P26: Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Oxidized Purine Nucleoside Triphosphate Hydrolase antibodyAnti-2-Hydroxy-Datp Diphosphatase antibodyAnti-7 -8-Dihydro-8-Oxoguanine Triphosphatase antibodyAnti-8-Oxo-Dgtpase antibodyAnti-Methylated Purine Nucleoside Triphosphate Hydrolase antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 1 antibodyAnti-Nudix Motif 1 antibodyAnti-NUDT1 antibodyAnti-MTH1 antibody |
Information sourced from Uniprot.org