Anti-NTAN1 antibody (1-310) (STJ117757)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NTAN1 (1-310) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NTAN1 |
| Gene ID | 123803 |
| Uniprot ID | NTAN1_HUMAN |
| Immunogen Region | 1-310 |
| Immunogen Sequence | MPLLVEGRRVRLPQSAGDLV RAHPPLEERARLLRGQSVQQ VGPQGLLYVQQRELAVTSPK DGSISILGSDDATTCHIVVL RHTGNGATCLTHCDGTDTKA EVPLIMNSIKSFSDHAQCGR LEVHLVGGFSDDRQLSQKLT HQLLSEFDRQEDDIHLVTLC VTELNDREENENHFPVIYGI AVNIKTAEIYRASFQDRGPE EQLRAARTLAGGPMISIYDA ETEQLRIGPYSWTPFPHVD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human NTAN1 (NP_775745.1). |
Additional Info
| Function | N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. |
| Protein Name | Protein N-Terminal Asparagine AmidohydrolaseProtein Nh2-Terminal Asparagine AmidohydrolasePnaaProtein Nh2-Terminal Asparagine DeamidasePnadProtein N-Terminal Asn AmidaseProtein N-Terminal Asparagine AmidaseProtein Ntn-Amidase |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein N-Terminal Asparagine Amidohydrolase antibodyAnti-Protein Nh2-Terminal Asparagine Amidohydrolase antibodyAnti-Pnaa antibodyAnti-Protein Nh2-Terminal Asparagine Deamidase antibodyAnti-Pnad antibodyAnti-Protein N-Terminal Asn Amidase antibodyAnti-Protein N-Terminal Asparagine Amidase antibodyAnti-Protein Ntn-Amidase antibodyAnti-NTAN1 antibody |
Information sourced from Uniprot.org